December07, 2022

Abstract Volume: 1 Issue: 1 ISSN:

Plasmapheresis for Treatment and Prevention of Late Pulmonary Complications in COVID-19 Infection

  Voinov V.A*, Ilkovich M.M1., Voinova Ya.V1

1. I.P. Pavlov First Saint Petersburg State Medical University, Saint Petersburg, Russia.

*Corresponding Author: Voinov V.A. I.P. Pavlov First Saint Petersburg State Medical University, Saint Petersburg, Russia.

Received Date:  August 14, 2020                                           

Publication Date: September 01, 2020                                           

Plasmapheresis for Treatment and Prevention of Late Pulmonary Complications in COVID-19 Infection

The COVID-19 pandemic affected more than 20 million people on Earth, of which more than 700,000 people died. However, even among the survivors, many have long-term consequences, with prospective serious health disorders.

The lungs are most often affected. In severe cases, acute respiratory distress syndrome (ARDS) develops such as toxic pulmonary edema with severe and difficult to correct the respiratory failure, which requires even extracorporeal membrane oxygenation. The main pathogenetic factor, in this case, is endotoxemia with the development of toxic interstitial, and then alveolar pulmonary edema due to the affected permeability of the cell membranes [1]. Activation of microbial infection with COVID-19 infection indicates a weakening of the body's immune defense system, its inability to cope with the pathological condition on its own. Respiratory viral infection contributes to immunosuppression even more, especially in patients weakened by chronic diseases, and intoxications.

At the same time, you can observe several immune disorders with an increase in the levels of C-reactive protein, IL-6, IL-8, as well as TNF-α, impaired T- and B- cell immunity [2, 3]. With this coronavirus infection, many toxic substances accumulate in the blood, up to a "cytokine storm" [4]. The main damage occurs in the vascular endothelium, leading to their porosity and release of not only fluid but also endotoxins into the interstitial space. With the development of such toxic vasculitis in the lungs, an acute inflammatory reaction occurs in the form of toxic edema that is the respiratory distress syndrome [1].

Already during the disease, serious disorders of all elements of their parenchyma are formed in the lungs with the development of small pulmonary vessels thrombosis, consolidation, and fibrosis in the later stages [5-7].

Such immune disorders do not go unnoticed. And after the cure, quite serious disorders remain associated with the formation of idiopathic pulmonary fibrosis. Thin-layer computed tomography reveals (parenchymal band, traction bronchiectasis, and irregular interfaces [8, 9].

There is a lot of evidence to support the autoimmune nature of such long-term complications after COVID-19 infection. One of the factors contributing to them is the affinity of the antigenic structure of the proteins of the virus and humans [10, 11]. Besides, disruption of the antigenic structure of damaged lung cells is a stimulus to form autoantibodies against them. And if viruses and microbes subsequently disappear from the body and the formation of antibodies against them subsides, then their damaged cells remain in the body forever, which is the stimulus for further formation of an autoimmune disease such as idiopathic pulmonary fibrosis, which will also develop for many years with symptoms increasing respiratory failure, up to the lethal outcome [12].

The severity of the complications caused makes it necessary to undertake serious measures for the rehabilitation of such patients after their recovery [13-17].

Given the autoimmune nature of these complications, it is most advisable to use plasmapheresis, with help of which not only autoantibodies and cytokines can be removed, but also many other toxic substances accumulated during the illness, including hepatic- and nephrotoxic drugs [18-19]. And if you use these methods of extracorporeal detoxification during an illness, you can prevent critical conditions and all long-term complications.



1.Voinov VA, Ilkovich MM, Kovalev MG et al. Acute respiratory distress syndrome. International Journal of Pulmonary and Respiratory Research 2019; 1:20-26.

2. George PM,  Wells AU,  Jenkins RG. Pulmonary Fibrosis and COVID-19: The Potential Role for Antifibrotic Therapy. Lancet Respir Med. 2020; 8(8): 807-815.

3.Yu M, Liu Y, Xu D et al. Prediction of the Development of Pulmonary Fibrosis Using Serial Thin-Section CT and Clinical Features in Patients Discharged After Treatment for COVID-19 Pneumonia. Korean J Radiol 2020;21(6):746-755.

4. Jamilloux Y, Henry T,  Belot A  et al. Should we stimulate or suppress immune responses in COVID-19? Cytokine and anti-cytokine interventions. Autoimmun Rev 2020;19(7):102567.

5. Francone M,  Iafrate F,  Masci GM et al. Chest CT score in COVID-19 patients: correlation with disease severity and short-term prognosis. Eur Radiol 2020 Jul 4;1-10.  doi: 10.1007/s00330-020-07033-y

6.Jing Wu, Junping Pan, Da Teng et al. Interpretation of CT signs of 2019 novel coronavirus (COVID-19) pneumonia. Eur Radiol 2020 May 4;1-8. doi: 10.1007/s00330-020-06915-5.

7.Rossi F,  Tortora C,  Argenziano M,  Di Paola A, Punzo F. Cannabinoid Receptor Type 2: A Possible Target in SARS-CoV-2 (CoV-19) Infection? Int J Mol Sci. 2020;21(11):3809.

8.Wang J ,  Wang BJ,  Yang JC et al. [Advances in the Research of Mechanism of Pulmonary Fibrosis Induced by Corona Virus Disease 2019 and the Corresponding Therapeutic Measures]. Zhonghua Shao Shang Za Zhi 2020;36(0):E006. [Article in Chinese]

9. Wei J, Yang H, Lei P et al. Analysis of Thin-Section CT in Patients With Coronavirus Disease (COVID-19) After Hospital Discharge. J Xray Sci Technol 2020;28(3):383-389.

10. Angileri F,  Legare S,  Gammazza AM,  Conway de Macario E  et al.  Molecular mimicry may explain multi-organ damage in COVID-19.  Autoimmun Rev 2020;19(8):102591.

11.  Lyons-Weiler J. Pathogenic Priming Likely Contributes to Serious and Critical Illness and Mortality in COVID-19 via Autoimmunity. Transl Autoimmun  2020 Apr 9;3:100051. doi: 10.1016/j.jtauto.2020.100051.

12. Voinov V.A. Therapeutic apheresis. Constatta, Celebris, 2016; 400.

13. Andrenelli E, Negrini F, De Sire A et al. Systematic Rapid Living Review on Rehabilitation Needs Due to Covid-19: Update to May 31st 2020. Eur J Phys Rehabil Med 2020 Jun 16. doi: 10.23736/S1973-9087.20.06435-7.

14.Grácio S,  Koçer S. [Rehabilitation Is Crucial for Severe COVID-19 Survivors]. Rev Med Suisse 2020;16(696):1170-1173. [Article in French].

15.Sheehy LM. Considerations for Postacute Rehabilitation for Survivors of COVID-19. JMIR Public Health Surveill 2020;6(2):e19462.

16.Zhao H-M,  Xie Y-X, Wang C. Recommendations for Respiratory Rehabilitation in Adults With COVID-19. Chin Med J (Engl) 2020 Apr 9.

17.  Vitacca M,  Lazzeri M,  Guffanti E et al. Italian Suggestions for Pulmonary Rehabilitation in COVID-19 Patients Recovering From Acute Respiratory Failure: Results of a Delphi Process. Monaldi Arch Chest Dis 2020;90(2).

18.Moeinzadeh F,  Dezfouli M,  Naimi A,  Shahidi S,  Moradi H. Newly Diagnosed Glomerulonephritis During COVID-19 Infection Undergoing Immunosuppression Therapy, a Case Report. Iran J Kidney Dis 2020;14(3):239-242.

19.Voinov VA, Ilkovich MM, Kovalev MG, Voinova YV. Extracorporeal Detoxification and Immunocorrection in Treatment of  Corona Virus Pneumonia Complications. Acta Scientific Gastrointestinal Disorders 2020; 3(5):12-17.


Volume 1 Issue 1 September 2020

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