August16, 2022

Abstract Volume: 3 Issue: 3 ISSN:

Successful IVF Pregnancy in Patient with Serous Borderline Ovarian Tumor

Dr. Mandavi Rai*

Corresponding Author: Dr. Mandavi Rai, (MBBS,M.S.OBGY,M.MAS,FRM,PGDS), Centre Head Indira IVF Hospital Private Limited, Noida.

Copy Right: © 2022 Dr. Mandavi Rai, This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Received Date: June 24, 2022

Published Date: July 01, 2022

Successful IVF Pregnancy in Patient with Serous Borderline Ovarian Tumor


Women seeking advice regarding pregnancy after completing treatment for ovarian cancer has increased (1-2). For women who has not done gamete preservation prior to cancer therapy, donor oocyte is ideal and cost e?ective option for fulfilling their desire to get pregnant. These patients should be advised by their oncologist regarding fertility preservation and future reproduction prior to starting treatment. Ovarian Malignancy constitutes about 15-20% of genital malignancy. It is the leading cause of cancer death in women next to breast cancer. 20 % ovarian neoplasm are malignant. It is more common in nulliparous women. Worldwide there are 2,39,000 new case and 1,52,000 deaths from ovarian cancer each year. Here we represent a case of patient with serous borderline tumour who underwent bilateral oophorectomy and went for IVF with donor eggs and had successful pregnancy in first attempt.

Case Report

The patient was 26 years old women who had Surgery in another hospital for bilateral large complex adnexal mass.She underwent laparotomy for bilateral tubo ovarian mass in 2015 with serous borderline tumour with micro invasion Her CA-125 was sent which was 297 and Cytopathology report showed features of Atypia. Her ultrasound finding showed right and left adnexa with large complex mass of size 85 * 105 mm and 75 *95 mm cystic with solid areas adherent to posterior side of uterus.

She had amenorrhoea post-surgery as she had undergone bilateral oophorectomy.She has been followed since than with vaginal ultrasound , CA-125 monitoring as well as yearly CT scan of abdomen and pelvis with no reoccurrence of tumour.

Patient got married in December 2019 and wanted to conceive. Since oophorectomy was done, she went for oocyte donation with anonymous donor. Hormonal support was given and transfer of two good blastocyst was done. Bhcg was done 15 days post transfer which was positive. She was given full hormonal support and patient conceived with twin pregnancy and delivered at 37 weeks.Both babies were normal with no evidence of malformation.


Since 1970s the WHO & FIGO Classify borderline ovarian tumour as ovarian epithelial tumour. (3-4) They are characterised by nuclear abnormalities, increased mitotic activity but unlike ovarian cancer, they are not infiltrative or have deconstructive growth or stromal invasion (5). Borderline tumour represents 10-20% of all ovarian epithelial tumours(6). Epidemiological data represents that one third of borderline patient are less than 40 years (7-8).

Therefore, preservation of childbearing potential plays important role in counselling patient with borderline tumour. Serous and mucinous borderline tumour are very common (9).

Overall reoccurrence rate is estimated between 3 & 10 % (10,11,12,13). A systematic review (7) showed that 37 % of reoccurrence are diagnosed during first 2 years, 31% in 2-5 years and 32% patients express relapse later than 5 years after diagnosis and 10% occurring after 10 years (7) with such long intervals of occurrence there is development of de no vo instead of real relapses (13-14).

ART Techniques have given new hopes and have increased the chances to have children as it allows women to safely conceive and deliver.

Fertility preservation option for single women are oocyte cryopreservation and for couples embryo cryopreservation can be performed.Controlled ovarian stimulation with fertility medication and timely retrieval of oocyte and embryo formation are done and they are cryopreserved. This helps couple for multiple attempts to achieve pregnancy.These procedures can be done without significant delay to cancer treatment. Donor oocytes are blessings   for women who have completed their cancer treatment which made them infertile, without prior fertility preservation in our case report.Timely reporting of patient to fertility specialist is mandatory. It is responsibility of oncologist to impart knowledge of various option of conception to young women for fertility preservation before undergoing treatment of cancer. On the other hand, gynaecologist should give the available option and treatment without delaying cancer treatment. So, team e?ort is required to communicate pros and cons of variable modalities available and e?ectiveness of treatment, possible risks for long term and cost of treatment so that patients can plan their treatment accordingly.


Thus, conception through fertility treatment for ovarian cancer does not a?ect their survival as seen in this case. Oocyte donation is a good option available for women who are infertile and had no option available as they did not preserve their gamete before cancer treatment. A multidisciplinary approach is always essential in such cases.


1. Braun M, Hasson-Ohayon I, Perry S, Kaufman B, Uziely B. Motivation for giving birth after breast cancer. Psychooncology 2005;14:282-96.

2. Partridge AH, Gelber S, Peppercorn J, Sampson E, Knudsen K, Laufer M, et al. Web-based survey of fertility issues in young women with breast cancer. J Clin Oncol 2004;22:4174-83.

3. Serov SF, Scully RE, Sobin LH. Histological Typing of Ovarian Tumours. Geneva: WHO 1973.

4. Classification and staging of malignant tumours in the female pelvis. Acta Obstet Gynecol Scand 1971; 50: 1–7. Volume 27 | Supplement 1 | April 2016 doi:10.1093/annonc/mdw090 | Annals of Oncology symposium article

5. Acs G. Serous and mucinous borderline (low malignant potential) tumors of the ovary. Am J Clin Pathol 2005; 123(Suppl.): S13–S57.

6. Lenhard MS, Mitterer S, Kumper C et al. Long-term follow-up after ovarian borderline tumor: relapse and survival in a large patient cohort. Eur J Obstet Gynecol Reprod Biol 2009; 145: 189–194. herman ME, Berman J, Birrer MJ et al. Current challenges and opportunities for research on borderline ovarian tumors. Hum Pathol 2004; 35: 961–970.

7.Sherman ME, Berman J, Birrer MJ et al. Current challenges and opportunities for research on borderline ovarian tumors. Hum Pathol 2004; 35: 961–970.

8. Sherman ME, Mink PJ, Curtis R et al. Survival among women with borderline ovarian tumors and ovarian carcinoma: a population-based analysis. Cancer 2004; 100: 1045–1052.

9. Du Bois A, Ewald-Riegler N, du Bois O, Harter P. Borderline tumors of the ovary— a systematic review [German]. Geburtsh Frauenheilk 2009; 69: 807–833 10.Tinelli R, Tinelli A, Tinelli FG et al. Conservative surgery for borderline ovarian tumors: a review. Gynecol Oncol 2006; 100: 185–191.

11. Kaern J, Trope CG, Kristensen GB et al. DNA ploidy; the most important prognostic factor in patients with borderline tumors of the ovary. Int J Gynecol Cancer 1993; 3: 349–358.

12. Mantzavinos T, Kanakas N, Genatas C et al. Five years’ follow-up in two patients with borderline tumours of the ovary hyperstimulated by gonadotrophin therapy for in-vitro fertilization. Hum Reprod 1994; 9: 2032–2033.

13. Rtiz BH, Ailawadi M, Colitti C et al. Second primary or recurrence? Comparative patterns of p53 and K-ras mutations suggest that serous borderline ovarian tumors and subsequent serous carcinomas are unrelated tumors. Cancer Res 2001; 61: 7264–7267