December09, 2022

Abstract Volume: 1 Issue: 1 ISSN:

Challenges in Transcatheter Closure of Patent Ductus Arteriosus in Adults

Harish Surwade* Parag Bhalgat1, Rahul Chhabria2

  1. Pediatric consultant cardiologist, Jaslok hospital and research center, Mumbai
  2. Consultant cardiologist, Jaslok hospital and research center, Mumbai

*Corresponding Author: Harish Surwade *. DNB Register in cardiology, Jaslok hospital and research center, Mumbai.

Received Date:  August 03, 2020                                           

Publication Date: September 01, 2020

Challenges in Transcatheter Closure of Patent Ductus Arteriosus in Adults


Transcatheter closure of patent arterial duct is standard of care and a well-established procedure in infants as well as grownups1. The procedure is carried out generally in infancy and the first few decades of life. It is extremely rare to find an open duct in the fourth or fifth decade of life. Closure of duct later in life can be challenging. Long-standing volume overload can change anatomy i.e. dilated pulmonary artery, dilated aorta, severe pulmonary hypertension, the abnormal orientation of duct, etc.

We wish to discuss a case of PDA device closure in 45 yr female and the challenges encountered along with the possible explanation for the same. (6), (7)


A middle-aged premenopausal lady, 45 yr presented with CL II symptoms. There were no risk factors like diabetes, hypertension, tobacco. On examination, she had a continuous murmur in Lt infraclavicular area. Pulse pressure was wide. Transthoracic echocardiogram showed a 7mm patent arterial duct with Lt to Rt shunt. There was volume overload on the left side. There was no other cardiac lesion. Pro and cons of PDA closure with the device were explained. (4)

After valid consent, the procedure was carried out under local anesthesia. Baseline hemodynamics were suggestive of wide puls pressure (Aorta 136/ 68mmHg) and elevated pulmonary artery pressure (40 /16mmHg).5 PDA was profiled in the left lateral and RAO 30 views. Due to dilated aorta, PDA ended on in the left lateral. In the RAO 30 view, PDA had a more vertical course than usual.

There was a big ampulla. The aorta as well as MPA were dilated. Multiple attempts to cross PDA from PA end with straight/angle tip wire with catheters like Judkin’s Right, multi-purpose A, etc failed. PDA was crossed from the Aortic end and the wire was parked in the left pulmonary artery. With wire as a landmark, one more attempt was made to cross PDA from the pulmonary artery. PDA could be easily crossed with MAP over an angled wire in the retrograde direction. After this Exchange length wire was parked in descending aorta and the delivery sheath was advanced in DTA. Wire in LPA was removed. PDA was closed with an 18*16 device as a standard procedure. The device was also setting more vertical than usual. Post-procedure there was no residual shunt.



In infancy and toddlers, the lie of PDA is more horizontal (2), (3). Great vessels are not of the size as seen in adults. With currently available hardware, the retrograde crossing of PDA is hardly met with difficulties. (7), (8), (9) In the present patient, due to age and long-standing shunt, there was significant dilatation of the main pulmonary artery and aorta. The vertical orientation of PDA may be due to the dilatation of great vessels. All these factors made the retrograde crossing impossible. Placing wire and catheter from the aortic end helped in more than one way10. It changed the orientation of PDA as well as provided landmarks for catheter and wire manipulation. Had it failed, snaring of wire from PA was the only option left?


1. Schneider DJ, Moore JW. “Patent Ductus Arteriosus”. Circulation 2006.

2. Campbell M. “Natural history of persistent ductus arteriosus”. Br Heart J 1968.

3. Bilkis A.A., Alwi M., Hasri S., Haifa A.L., Geetha K., Rehman M.A., and Hasanah I “The Amplatzer duct occluder: experience in 209 patients”. J Am Coll Cardiol 2001.

4. Masura J., Tittel P., Gavora P., and Podnar T,“Long-term outcome of transcatheter patent ductus arteriosus closure using Amplatzer duct occluders”. Am Heart J 2006.

5. Young HJ, Tae JY, Jong MS, Jung JP, Dong MS, Jae KK, et al. “Left ventricular remodeling and change of systolic function after closure of patent ductus arteriosus in adults: device and surgical closure”. Am Heart J 2007.

6 Rigby ML. “Closure of a large patent ductus arteriosus in adults: first do no harm”. Heart 2007.

7.Yan C, Zhao S, Jiang S, Xu Z, Huang L, Zheng H, et al. “Transcatheter closure of patent ductus arteriosus with severe pulmonary arterial hypertension in adults”. Heart 2007.

8. Rigby ML. “Closure of a large patent ductus arteriosus in adults: first do no harm”. Heart 2007.

9.Schneider DJ, Moore JW. “Patent Ductus Arteriosus”. Circulation 2006.

10. Jou KW, Mei HW, Juey JH, Fu TC, Ming TL, Hung CL. “Transcatheter closure of moderate to large patent ductus arteriosus with amplatzer duct occlude”. Cathet Cardiovasc Int 2007.


Volume 1 Issue 1 September 2020

©All rights reserved by Dr. Harish Surwade.

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