Pleomorphic Adenoma of the Parotid Gland: Case Report

Pleomorphic Adenoma of the Parotid Gland: Case Report

 

Juan Carlos Quintana Díaz *1, Carlos Alberto Botella Suarez 2, Evis Johnson Montero 3, Odalys Pacheco Sasplugas 4, Lilianne Marcel Johnson 5

 

  1. Maxillofacial Surgeon. Associated Professor, Princess Marina Hospital, Gaborone, Gaborone, Botswana. Orcid: 0000-0002-8629.
  2. Maxillofacial Surgeon, Princess Marina Hospital, Gaborone, Gaborone, Botswana. Orcid:0000-0002-7025-0588
  3. Pediatrician Associated Professor, Princess Marina Hospital, Gaborone, Gaborone, Botswana. Orcid: 0000-0002-7721-3800.
  4. Especialista primer grado en Anatomia Patologica, Princess Marina Hospital, Gaborone, Botswana. Orcid: 0000 0001-9301-7028.
  5. Estomatologo General, Princess Marina Hospital, Gaborone, Botswana, Orcid 0009-0002-4859-479.

 

*Correspondence to: Juan Carlos Quintana Díaz. Maxillofacial Surgeon. Associated Professor, Princess Marina Hospital, Gaborone, Gaborone, Botswana. Orcid: 0000-0002-8629.

           
Copyright.

© 2026 Juan Carlos Quintana Díaz, This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Received: 21 April 2026

Published: 01 June 2026

DOI: https://doi.org/10.5281/zenodo.20473119

 

Abstract

Background: Pleomorphic adenomas are benign salivary gland tumors, which predominantly affect the superficial lobe of the parotid gland. The “pleomorphic” nature of the tumor can be explained on the basis of its epithelial and connective tissue origin. The tumor has a female predilection between 30–50 years of age. Slowly progressing asymptomatic swelling is the usual presentation of the tumor. Surgical excision of the tumor mass forms the mainstay of treatment, with utmost care taken to preserve the facial nerve.

Case Details: This case report aims to throw light on an interesting case of pleomorphic adenoma of the parotid gland in a 65 years old female patient. The patient presented with a slowly progressing asymptomatic swelling on the right side of the face. There is also a special emphasis to a detailed review of literature.

Conclusion: Salivary gland neoplasms can occur at any site where salivary tissue is present. Pleomorphic adenoma is the commonest salivary gland tumor characterized by diverse histomorphological features. Early diagnosis and treatment plan entails thorough history taking, clinical examination, coupled with radiographic and histopathological findings

Keywords: Benign salivary gland tumors, Pleomorphic adenomas, Parotidectomy.


Pleomorphic Adenoma of the Parotid Gland: Case Report

Introduction

Pleomorphic adenoma (PA), also known as benign mixed tumor, is the most common salivary tumor, constituting up to two-thirds of all salivary gland neoplasms (1). Mostly, PA is located in the parotid glands (85%), minor salivary glands (10%), and the submandibular glands (5%) (2). In the majority of cases, tumors originate in the superficial lobe. However, occasional cases may involve the deep lobe of the parotid gland (3) and the parapharyngeal space. Minor salivary gland tumors are frequently encountered on the palate, followed by the lip, cheek, tongue and floor of the mouth (4). PA usually manifest as a slow progressing asymptomatic, parotid gland swelling without facial nerve involvement (5). They are best treated by a wide local excision with good safety margins and follow-up for at least 3–4 years (6).

 

Case Report

A 65 years old female patient reported to the Outpatient Department with a chief complaint of slow growing, painless swelling on the right side of face since 10 years, patient complains afraid to receive surgical treatment. The swelling was initially small in size and had progressively increased with time to attain the present size. Past medical and surgical history was hypertension. Extra-oral clinical examination revealed a marked facial asymmetry. A well-defined, ovoid, unilobular swelling, 8× 10 cm in diameter was seen on the right side of the face. The swelling had a superioinferior extent from right zygomatic arch to about 2 cm below the lower border of mandible and anteroposterior extent from mid body region to the posterior border of mandible. The right ear lobule was slightly everted. Loss of wrinkling of the skin and engorged veins was also seen (Figure 1,A,B)

The swelling was firm in consistency, non-tender and warm on palpation. It was fixed to the underlying structures and the overlying skin. Facial and eye movements were normal on examination, no Bell palsy. Intraoral clinical examination was unremarkable. A provisional diagnosis of benign tumor of the right parotid gland was taken into consideration. Pleomorphic adenoma, Warthin's tumor and neuroma of the facial nerve (nerve sheath tumor) were considered as the most probable differential diagnosis. Warthin's tumor is usually seen in elderly males with a history of smoking, does not cause eversion of the ear lobe, located in the lower portion of the parotid (near angle of mandible), and 10–15% cases show bilateral involvement. Benign tumor of nerve sheath origin in the parotid gland poses difficulty in preoperative diagnosis because of the low frequency of occurrence (0.2% to 1.5%). Also, preoperative diagnosis of a parotid tumor as neuroma seems challenging without accompanying facial nerve dysfunction.

Fine Needle Aspiration (FNA) was prescribed and performed under local anesthesia, the Histopathologically diagnosis was confirmed and correlative with clinically examination, Pleomorphic Adenoma

Panoramic radiographic examination did not reveal any abnormality.  Ultrasonography of the right parotid gland showed a hypoechoic area, well define, oval shape, no fluids and smooth margins.

After obtaining the informed consent of the patient, excision of the superior lobe of the right parotid gland along with the tumor mass was made. A modified Blair incision was given to the right preauricular region; platysma muscle and superficial musculoaponeurotic layer were dissected. The peripheral nerve branches were identified and preserved following a retrograde approach. Nerves were separated from the underlying parotid gland. The tumor was resected after separation from the facial nerve and the masseter muscle (Figure 2 A,B).

The excised tumor mass was 8cms × 10cms × 12cms in dimension. (Figure 3). Histopathology revealed a well capsulated, highly cellular mass with interspersed epithelial cells and myoepithelial cells containing eosinophillic cytoplasm. Presence of mucoid material between the tumor cells imparted a myxomatous background. Chondroid and ductal areas along with fat and osteoid were also seen (Figure 4). Pleomorphic adenoma, myoepithelioma and adenoid cystic carcinoma were considered as the probable histologic differential diagnosis. The presence of chondromyxoid foci along with glanduloductal differentiation excluded the histological diagnosis of myoepithelioma. Lack of infiltrative growth pattern and perineural invasion ruled out adenoid cystic carcinoma. The characteristic features of chondromyxoid foci and glanduloductal differentiation confirmed the diagnosis of pleomorphic adenoma of the right parotid gland.

 

Discussion

World Health Organization (1972) defined PA as a well-defined tumor characterized by its pleomorphic or mixed appearance. There is intermixing of the clearly recognizable epithelial component with mucoid, myxoid and chondroid component (7). Although the lesion presents several histological features due to the different compounds with a myxoid or chondroid matrix, it is generally considered to be a benign neoplasm (8,9).

The exact etiology is obscure although the incidence increases from 15–20 years after exposure to radiation. Few studies have suggested an association of the tumor with simian virus 40 (SV 40) (10).

Pleomorphic adenomas are generally discovered during routine physical examination, as an asymptomatic mass. PA has a glandular origin in the head and neck region and usually manifests as a mobile, slow progressing, asymptomatic firm swelling that does not cause ulceration of the overlying mucosa (11). The majority of these tumors measure 2–6 cm in size when excised (12). However, large tumor may be seen as a single, irregular nodular mass stretching the overlying skin or mucosa (13). The tumor may weigh from several grams to more than 8 kilograms (14). Parotid gland PA is usually seen below the lobule of the ear and overlying the angle of the mandible. Facial nerve weakness is an infrequent sign in parotid tumors although large neglected tumors may present with facial nerve weakness (15, 16). Oral retrotonsillar mass/ parapharyngeal space tumor may be a presenting sign in cases of deep lobe involvement (17).

Based on clinico-pathological and immune-histochemical features of 60 cases of PA in Brazil, Alves et al. Reported that the tumor occurred commonly between the 3rd and 5th decades of life, and 37/60 (62%) of the affected patients were women (18).

Our patient was a 65 years old female who presented with a slowly enlarging, multilobular, asymptomatic swelling on the left side of the face since 10 years. The swelling caused stretching of the overlying skin with visible engorged veins and slight deflection of the left ear lobule. The ocular and facial movements were normal, suggestive of intact facial nerve functions. Grossly, the excised tumor mass measured 8 × 10 × 12 cm in diameter. The features in the present case were consistent with the previously published literature.

Ultrasonographic findings of the present case showed a hypoechoic area in the left parotid gland. FNAC is a reliable procedure that can guide the surgeon to choose the right surgical approach (5, 19,20, 21). The procedure is usually performed following diagnostic imaging to rule out a vascular lesion although it is not the first choice diagnostic tool (22).

The present case showed a combined pattern of epithelial, myoepithetial and mesenchymal components on FNAC. The histopathology presents varied morphological patterns, showing epithelial and myoepithelial cells with interspersed areas of mesenchymal differentiation. Epithelial cells typically form duct-like structures associated with non-ductal cells presenting varying shapes and forms. Myxoid, cartilaginous, hyaline, or osseous differentiation is appreciated in the stromal component. The stroma is presented as a mixture of gland-like epithelium and mesenchyma-like tissue in varying proportions (13).

As pleomorphic adenoma exhibits a varied histopathologic presentation, it may be confused histopathologically withmyoepithelioma, Adenoid cystic carcinoma, mucoepidermoid carcinoma and basal cell adenoma.

Myoepitheliomas may be considered as a variant of pleomorphic adenoma, but lacking the typical feature of glandulo ductal differentiation (23). Another characteristic feature of myothelioma is the absence of chondromyxoid or chondroid foci (24). Chondromyxoid foci and glanduloductal differentiations are the hallmark feature in pleomorphic adenomas.

Adenoid cystic carcinoma shows epithelial and myoepithelial differentiation in three forms: Cribriform, Tubular, and Solid (25). However, the infiltrative growth pattern and tendency for perineural invasion are the salient features of adenoid cystic carcinoma.

The intermediary cells in mucoepidermoid carcinoma show similarity to the basal/myoepithelial cells of pleomorphic adenoma. Although the intermediary cells have the potential to produce the extracellular material, they lack the ability to create the myxochondroid stroma. Also, squamous differentiation (when present in pleomorphic adenoma) is generally well developed and may show keratinisation. This feature is less evident in carcinoma (26).

Basal cell adenoma is a subtype of pleomorphic adenoma, and was previously termed as monomorphic adenoma. The tumor can be histologically differentiated from pleomorphic adenoma by the absence of chondromyxoid stroma and the presence of a uniform basaloid epithelial pattern.

Histopathological features in the current case showed salient features of pleomorphic adenoma. A well-capsulated cellular mass of sheets and islands of epithelial cells and rounded myoepithelial cells, along with myxomatous background and ductal architecture, was clearly evident.

Aggressiveness and extent of the tumor mass and its relation with the facial nerve form the important criteria which dictate the choice of treatment of pleomorphic adenoma of the parotid gland. Enucleation, enucleoresection and superficial or total parotidectomy with preservation of the facial nerve formed the mainstay of surgical treatment (27).

In the present case, superior lobe of the right parotid gland with the tumor mass was excised with utmost care to preserve the facial nerve branches. Pleomorphic adenomas need to be managed diligently as they have a tendency for recurrence and malignant transformation. Rupture of the capsule and subsequent tumor spillage during excision are attributable risk factors for recurrence. Up to 10% cases show malignant transformation and features predictive of malignant change include advancing age, massive tumor size, a long duration of the mass, occurrence in submandibular salivary gland, and hyalinized connective tissue (28).

The patient in the current case was thoroughly followed up for a period of 2 years and no signs of recurrences were observed during the follow up.

 

Conflicts of Interest.

The authors declare no conflicts of interest.

 

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