Volume 2 Issue 5

Giant Left Atrial Myxoma Revealed in A Setting of Myocardial Infarction: A Case Report

Haimida Madi *, Chighaly .El Hadj1, Haletine Ag Elmehdi1, khaled.Boye1

 

  1. National center of cardiology, Nouakchott-Mauritanie


Corresponding Author: Haimida Madi, National center of cardiology, Nouakchott-Mauritanie.

Copy Right: © 2022, This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Received Date: September 26, 2022

Published Date: October 01, 2022

 

Abstract

Myxomas are the most common benign cardiac tumors. They usually manifest as symptoms due to atrioventricular valve obstruction or embolization events.

Coronary embolization is a rare but potentially fatal complication.

We report the case of a 53-year-old female patient who presented to the cardiology emergency ward with acute chest pain and dyspnea NYHA class 2 to 3. The electrocardiogram (EKG) showed an ST elevation, troponins came back negative, coronary angiography was done immediately without any abnormality and a transthoracic electrocardiogram (TTE), showed a large mass in the left atrium obstructing the mitral valve evoking a left atrial myxoma.

The patient was operated on for surgical resection of the mass, the histological nature of the myxoma was confirmed. 

We report this case with a review of the literature as a finding.


Giant Left Atrial Myxoma Revealed in A Setting of Myocardial Infarction: A Case Report

Introduction

Cardiac tumors are rare, Primary cardiac tumors represent about 5% of cardiac tumors, and their occurrence is estimated to be less than 0.03% [1]. and their occurrence is estimated to be less than 0.03% [1]. About 90% of primary cardiac tumors are benign. The most common type of benign heart tumor is myxoma which appears in the left atrium (LA) in 75-85% of cases [2, 3] They usually occur more in women and after the third decade of life [4]. The tumor can cause obstruction of the atrioventricular valve as well as the embolization event by throwing clots into the systemic and pulmonary circulation [1, 5]. Atrial myxoma causes embolization into the systemic circulation in 30-40% of cases [6], which can cause severe neurological manifestations and cardiac manifestations: arrhythmia, heart failure, and pericardial effusion [1]. The manifestations of myxoma depend on its size, location, and mobility [7]. Patients may present with polymorphic clinical patterns and might be asymptomatic [8]. Transthoracic echocardiography (TTE) remains the key examination for the diagnosis of myxoma [9]. Surgical removal of the tumor mass is the optimal treatment [1].

We report a case of incidental finding of a large left atrial myxoma in a 54-year-old female patient who initially came in with acute coronary syndrome.

 

Case Presentation

We report the case of a 53-year-old female patient who presented to the cardiology emergency ward with acute chest pain and dyspnea NYHA stage 2 to 3. The EKG revealed an ST shift in two leads, troponins came back negative, coronary angiography was done immediately without any abnormalities and a TTE revealed a large mass in the left atrium obstructing the mitral valve, evoking a left atrial myxoma.
The patient was operated on for surgical resection of the mass, and the histological nature of the myxoma was confirmed. The postoperative follow-up was good.

We report this case with a review of the literature.

 

Discussion

In left atrial myxoma there are no specific signs and the patterns of findings are very polymorphic and related to the size, location and mobility of the tumor. (obstructive, embolic or constitutional). (9)

Myxoma syndrome presents with : fever, weight loss, arthralgias

The association between coronary syndrome and myxoma has been reported in 70 cases in the literature to date.

In 1/3 of the cases the myxoma embolizes into the systemic circulation but in the coronary arteries, the incidence is 0.06%, which makes acute myocardial infarction a rare manifestation of early myxoma.

The first explanation is related to the fact that the coronary ostia are disposed in perpendicular position to the aortic flow and the second is that the opening of the aortic cusps in systole protects the ostia from coronary events. (9)

This value is thought to be underestimated, either because of the lack of systematic echocardiographic evaluation of all patients with acute myocardial infarction or due to the lack of published data related to fatal events. Hence the extreme importance of performing an echocardiographic evaluation of patients with acute myocardial infarction before initiation of targeted therapy, as this will be the only way to avoid the potentially deleterious use of thrombolytic agents that may increase the risk of myxoma embolization, either by lysis of accumulated thrombus, or by hemorrhage and rupture of small fragments (10).

Embolization of the anterior descending and left circumflex coronary arteries has been reported, In a considerable number of cases, no coronary lesion was found on angiography, which may be explained by the high rate of recanalization of coronary embolisms from myxomas (10) .

In our case, the left atrial myxoma was giant multipoid with an irregular and very friable surface, which prolapsed through the orifice of the mitral valve.

Once the diagnosis of myxoma is made, resection surgery is the only effective treatment and must be performed immediately due to the imminent danger of embolization. The short- and long-term prognosis is excellent, and recurrence is rare, however, semi-annual echocardiographic follow-up is recommended in all cases (1).

With this clinical case, we intend to alert to the fact that a diagnosis as common in our daily clinical practice as acute myocardial infarction can be the manifestation of a rare entity such as atrial myxoma, and that an embolic source should always be checked.

In cases of myocardial infarction with angiographically normal coronary arteries. The lack of atherosclerotic lesions or coronary thrombi is in concordance with the high rate of recanalization documented in myxoma emboli, especially in those with extremely friable surfaces, as in the case described. (9)

We also highlight the fundamental importance of echocardiography, in this case, performed early in the patient's approach.


Conclusion

Even though it is very rare for myxoma to cause acute myocardial infarction, in front of an acute coronary syndrome, echocardiography can make the diagnosis of a left atrial myxoma and allow a correct diagnosis and an immediate referral to the only treatment that could avoid a potentially fatal outcome.


References

1. Shrestha S, Raut A, Jayswal A, Yadav RS, Poudel CM. Atrial myxoma with cerebellar signs: a case report. J Med Case Rep. 2020;14(1):29. [PMC free article][PubMed] [Google Scholar]

2. Kunioka S, Fujita K, Iwasa S, Murakami H, Kamiya H, Yamazaki K, et al. A rare form of cardiac myxoma: interatrial septum tumor. J Surg Case Rep. 2020;2020(9):rjaa333. [PMC free article] [PubMed] [Google Scholar]

3. Kearney A, Corry N, Menown IBA. Massive left atrial myxoma presenting with troponin-positive chest pain. Cardiol Ther. 2020;9(2):577–580. [PMC free article][PubMed] [Google Scholar]

4. Kohno N, Kawakami Y, Hamada C, Toyoda G, Bokura H, Yamaguchi S. Cerebral embolism associated with left atrial myxoma that was treated with thrombolytic therapy. Case Rep Neurol. 2012;4(1):38–42. [PMC free article] [PubMed] [Google Scholar]

5. Azhar A, Ziyadi G, Zulkarnain H, Rahman M. Atrial myxoma presenting as a cerebellar stroke. J Surg Acad. 2011;1(2):36–40. [Google Scholar]

6. Azdaki N, Moezi S, Hosseinzadehmaleki M, Farzad M. Failed primary percutaneous coronary intervention in a middle-aged man without cardiovascular risk factors: left atrium myxoma. Pan Afr Med J. 2020;36:6. [PMC free article][PubMed] [Google Scholar]

7. Bernatchez J, Gaudreault V, Vincent G, Rheaume P. Left atrial myxoma presenting as an embolic shower: a case report and review of literature. Ann Vasc Surg. 2018;53:266. [PubMed] [Google Scholar]

8. Cho J, Quach S, Reed J, Osian O. Case report: left atrial Myxoma causing elevated C-reactive protein, fatigue and fever, with literature review. BMC Cardiovasc Disord. 2020;20(1):119. [PMC free article] [PubMed] [Google Scholar]

9. Latifi AN, Ibe U, Gnanaraj J. A case report of atrial myxoma presenting with systemic embolization and myocardial infarction. Eur Heart J Case Rep. 2019;3(3):ytz1104. [PMC free article] [PubMed] [Google Scholar]

10. Negi R, Chauhan V, Sharma B, Bhardwaj R, Thakur S. Atrial myxoma: a rare cause of ischemic stroke. J Assoc Phys India. 2013;61(4):280–282. [PubMed] [Google Scholar]

11. Dubey L, Chaurasia AK. Neovascularization in left atrial myxoma. Int Cardiovasc Res J. 2012;6(4):133–134. [PMC free article] [PubMed] [Google Scholar]

12. Wu Y, Fu XM, Liao XB, Zhou X. Stroke and peripheral embolisms in a pediatric patient with giant atrial myxoma: Case report and review of current literature. Medicine (Baltimore) 2018;97(30):e11653. [PMC free article] [PubMed] [Google Scholar]

13. Lum PT, Sekar M, Gan SH, Pandy V, Bonam SR. Protective effect of mangiferin on memory impairment: a systematic review. Saudi J Biol Sci. 2021;28(1):917–927.[PMC free article] [PubMed] [Google Scholar]

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