Reveal the molecular principle of coronavirus disease 2019 (COVID-19)
Lin Fang1, Xinlei Wang4, Zhongyuan Lai1,2, Dongdong Zhang1, Mengqu Wu1, Zhirui Pan1, Li Wang1, Kun Tang1, Dahong Qian1,3, Zhende Huang1,3, Xudong Wang1*, Haibo Chen4*, and Kuo-Chen Chou

1Deepblue Academy of Sciences, Deepblue Technology (Shanghai) Co., Ltd, 369 Weining Rd, Shanghai 200050, China.

2Department of Physics, Fudan University, Shanghai 200433, China.

3School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.

4Deepblue Technology (Shanghai) Co., Ltd, 369 Weining Rd, Shanghai 200050, China.

*Corresponding Author: Dr. Kuo-Chen Chou *, 4Gordonlife Science Institute, Boston. MA 02418, USA
 

Received Date:  November 07, 2020

Publication Date: December 01, 2020

Figure 1: The Alignment of the Amino Acid Sequences of the S Proteins from 4 Coronaviruses and The Phylogenetic Tree of the Genes of the Receptor Binding proteins from 8 Different Single Strand RNA Viruses with the MEGA software.

Top: The Alignment of the Amino Acid Sequences of the S Proteins from 4 coronaviruses, namely Bat Coronavirus RaTG13, Pangolin CoV(GX), SARS-CoV  (NC_004718) and SARS-CoV-2 (NC_045512). Receptor Binding Domain (RBD) are labeled with the color boxes and the black arrows indicate the beginning and the end of RBD.

Refer Figure 1,2,3

Figure 7:

The Alignment of the Spike?S?Protein of 3 strains of SARS-CoV-2 and 1 Strain of SARS-CoV (NC_004718.3), SARS-CoV-2?NC_045512?, MT415375 and MT415377. Important functional regions, such as the signal peptide (SP), Receptor Binding Motif (RBM), Fusion Peptide (FP) and the inserted amino acid (amino acids PRRA)/host protease recognition site and cleavage site (amino acids RRAR)/cleavage site (between amino acids 685R and 686S) have been marked on the CA pictures.

SP: green Box (the green arrows showing the beginning and end of the SP); RBM: blue box (the blue arrows showing the beginning and end of the RBM); PRRAR: black box (the black arrows showing the beginning and end of the inserted/host protease recognition amino acid sites; the red arrow showing the host protease cleavage site between amino acids 685R and 686S) ?T. Meng, et al.?; FP: yellow box.

Refer Figure 4,5,6

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Refer to the attached pdf for all references.

Volume 1 Issue 4 December 2020

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